MI (26-11), which made its last Sweet 16 appearance in 2014, and continues its insane run, having won 12 of 14 games.
Not often does MI find itself in a game with both teams passing 90 points, but the NCAA Tournament brings about much different foes than the regular season. This years quest continued with 78-63 win versus Jacksonville State in their NCCA opener.
MI has used poise, emotion and experience to reel off six straight wins.
Blair Schaefer scored 18 points, Jazzmun Holmes added 14 and Mississippi State beat DePaul 92-71 on Sunday in the second round of the NCAA Tournament. Wagner and Wilson will need to combat Louisville's big men: Deng Adel and Mangok Mathiang. North Carolina and Duke are the only ACC teams still competing for the title. MI made 16 three pointers, with 11 of those coming in the second half.
The Wolverines advance in the NCAA's Midwest Regional, where they'll face either OR (30-5) OR Rhode Island (25-9) on Thursday in Kansas City, Mo. But the Wolverines are only 3 of 11 and getting few open shots from beyond the arc.
Wagner logged a career-high 26 points (14-14 FG) in 31 minutes, while Wilson had 17 points (6-13 FG, 4-4 FT) and three blocks.
With Michigan trailing 36-28 at halftime, coach John Beilein said his team was capable of mounting the same kind of run.
Michigan-Louisville will be a tale of a great offensive team facing a great defensive team.
Yet the Big Ten already has sent three teams to the Sweet 16 with Purdue, Wisconsin and MI advancing.
Louisville, meanwhile, missed opportunities, shooting just 5-for-20 from the perimeter and also missing some shots around the basket.
Johnson laughed about the story on Saturday, insisting that, more than three years later, it didn't matter.
For the first time in weeks, someone other than Derrick Walton Jr. had to take the reins.
"[We're] very disappointed we lost", Louisville coach Rick Pitino said, "It's always a disappointment, but we played a good game, especially in the first half".
In the backcourt, Quentin Snider and Donovan Mitchell are both threats to put up big points.